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M94A0659.TXT
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1994-10-21
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Document 0659
DOCN M94A0659
TI Neuropsychological impairment in AIDS dementia complex (ADC):
preliminary results.
DT 9412
AU Dunbar N; Brew B; National Centre in HIV Epidemiology and Clinical
Research,; University of New South Wales, Sydney.
SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:53 (abstract no. SP1).
Unique Identifier : AIDSLINE ASHM5/94348996
AB AIM: To develop a predictive model of neuropsychological impairment in
ADC. METHOD: HIV+ homosexual men were recruited. Eligibility criteria
were: CD4+ cell count < 200, no acute systemic illness,
psychiatric/neurologic/i.v. drug history. Subjects were
neuropsychologically and neurologically assessed at baseline and at 4
monthly intervals for 1 year. A control group of HIV-homosexual men were
recruited to participate in the baseline neuropsychological section of
the study only. The neuropsychological test battery assessed the
functions of memory, information processing, motor performance,
conceptual flexibility, language and spatial ability. RESULTS: To date
50 HIV+ subjects and 18 HIV- subjects have been recruited. The first
preliminary analysis was on the neuropsychological performance of 18
HIV+ nondemented subjects matched with the control group for age and
years of education. The groups were compared using parametric and
non-parametric methods. The HIV+ group performed significantly worse
than the control subjects in the following areas: verbal and visual
memory, motor performance, and information processing. The second
analysis involved 23 HIV+ subjects who had completed 2 visits. The only
significant changes were associated with a minor improvement in
performance on some tests of memory, visuospatial ability and learning,
probably indicative of a practice effect. CONCLUSION: This severely
immunodeficient clinically nondemented HIV+ group had significant
neuropsychological impairment in the areas of memory, motor performance
and information processing. There was no progression of impairment after
4 months. This pattern of impairment is also observed in demented
patients, suggesting that these areas of function may be early markers
for the development of ADC.
DE Adult AIDS Dementia Complex/*DIAGNOSIS/PSYCHOLOGY Comparative Study
Homosexuality/PSYCHOLOGY Human HIV Seronegativity HIV
Seropositivity/DIAGNOSIS/PSYCHOLOGY Male *Neuropsychological Tests
Problem Solving Psychomotor Performance Recall MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).